Hip Replacements and Aseptic Loosening

A detailed Summary of Hip Replacements and Aseptic Loosening


Total hip replacements are devices that are considered highly successful in relieving pain and restoring movement. They are commonly made from ceramic, plastic or metal materials. However, the continuing problems with wear and particulate debris can eventually require further surgery, including totally replacing the prosthesis. Here, we will discuss the biological mechanisms of how wear debris can cause the condition 'aseptic loosening'. Different design strategies orthopedic researchers are focusing on to eliminate this problem will also be discussed.

Wear debris from devices used in total hip replacements can cause a condition called aseptic loosening. Aseptic loosening is a loosening of the total joint that is not caused by bacteria.4 It is attributed to wear particles of the implant, tissue response dominated by macrophages and degrading enzymes.2 In a loose total joint, the joint lies in a cavity


Orthopedic researchers are hard at work developing strategies to eliminate the problem of aseptic loosening. Studies into identification of genes that cause musculoskeletal deformities, proteomics, and cloning have advanced remarkably. Orthopedic surgeons look forward to the use of 'gene chips' that would allow them to review genetic analysis and select therapies tailored to the patient's biological makeup. New materials such as titanium and titanium alloys have helped. Advances in nanotechnology allows for the structure and function of body tissues to be created and mimicked in laboratories. Thanks to these advances, it is predicted that in the near future, use of plastics and metals will be replaced with use of cell-based materials. With the increased knowledge of factors controlling bone development and cell differentiation, composite materials will be fashioned that facilitate in-growth.1

that forms around it that is padded with loose

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Approximate Word count 642
Approximate Pages 3 250 words per page double spaced

Category: Science

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