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KLINEFELTER'S SYNDROME

Klinefelter's syndrome is a genetic disorder that is only found in males. Until recently you could not detect this disorder until after puberty, but now they can detect it before birth using amniocentesis. Amniocentesis is the use of a long needle to withdraw amniotic fluid surrounding the fetus. Klinefelter's syndrome was first discovered by H.F. Klinefelter in 1942. This disease affects about one in one thousand males that are born.

Klinefelter's syndrome is caused by an extra X chromosome, which is caused by an error in meiosis, to make a combination of XXY, also known as a trisomal karyotype. Although the extra X chromosome is inactive, also known as a Barr body, it still interferes with the development of some male characteristics. Other causes of this disease are excessive alcohol intake, hormone disturbance, and urinary tract infections. Some STD's such as syphilis and non specific urethritis can cause a male to get this disease also. The older a woman is when she gives birth to her child the more likely the son is to have Klinefelter's syndrome. Even so, it is not a hereditary disease.

Along with the interference of the development of male characteristics, Klinefelter's can cause s


omeone to have some mental retardation; the condition does not worsen, nor does it get better, after birth. As the number of X chromosomes increase the severity of mental retardation and malformation will also increase. Some other effects of this disease are the plasma concentration of the male hormone testosterone is often low and they are unable to impregnate a female, in other words they are sterile. Someone with Klinefelter's syndrome often has trouble learning to read and write this will often times cause them to speak later than others. Klinefelter's syndrome can cause problems with a males genitals and his endocrine system. Some physical effects of this disease are that a person tends to be taller, have longer limbs, and their testes are small and firm. In some cases a male may form breast tissue. Many males infected with this disease will also have reduced muscle development. There is also excessive loss of sexual stimulating hormones in the urine.. It is said that a male with Klinfelter's syndrome is most often very talented in arts and mechanics.

After the cells have had a chance to grow the doctors will test them for certain genetic disorders.

Klinefelter's syndrome is a very common disease even though it goes undetected in many males. Not many people know about this and many other genetic diseases which could be affecting someone in their family or just someo

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Approximate Word count = 939
Approximate Pages = 4 (250 words per page double spaced)


  

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