Stereochemistry Considerations
What would you think if I gave you a drug and said this is going to help you but I want you to know ahead of time that 50% of the dose is not affected, in fact the drug is 50% not pure. The idea of that would make you feel you want another drug. The reality of that is that a large # of drugs we give are 50% impure and the reason is b/c so many drugs we give are racemic mixtures, a 50:50 mixture of enantiomers. Most drugs that demonstrate optical activity only one isomer is pharmalogically active, so what that means is that we are giving a product where 50% of it is inactive. There are some important considerations you have to take into account when you have drugs that are optically active and what we would like to do today is take the things we have gone thru this semester where we have really ignored stereochemistry thru that whole process and talk about the times in which you need to consider aspects of stereochemistry. This has become a big issue now the FDA has pushed for drug companies to be able to characterize both isomers when giving a racemic mixture, also to force manufactures to only market the active isomer and not going with the standard practice of giving a drug which is
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Some common words found in the essay are:
Significance Stereoisomers, Nomenclature Remember, Stereochemistry Considerations, S-IBU R-IBU, Louis Pasteur, RS SR, S-IBU CoA, R-/S- R---, plane polarized light, polarized light, optically active, plane polarized, geometric configuration, racemic mixtures, racemic mixture, pure enantiomer, isomer potent, organic chemistry, absolute configuration, rr isomer potent, difference geometric configuration, rotation plane polarized, activity rr isomer, RR SS, SS RS,
Approximate Word count = 4674
Approximate Pages = 19 (250 words per page double spaced)
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