immunology grant proposal

A detailed Summary of immunology grant proposal

I will be addressing the possible immunological barriers that may be involved with challenge

to infection of Toxoplasmosa gondii, the protozoan that causes toxoplasmosis. It is widely known

that toxoplasmosis is a devastating disease, with often drastic consequences upon infection. In

pregnant mothers, these consequences can be very horrid. Such effects are more felt by the unborn

fetus than by the mother. These effects include abortion, premature birth, and severe growth

retardation (Creasy et. al., 1994). Falkner et. al. have shown that the human fetus is capable of

producing antibodies as early as ten weeks gestation time. We also know that antibodies to

toxoplasmosis exist, which are of Ig G, Ig M, and, recently demonstrated, although in low levels, Ig

These facts give rise to some questions regarding the bizarre reactions of the fetus, which

should be more than protected enough from infection. Why is the fetus damaged, or even aborted

from such a challenge, when it has the ability to produce antibodies? Are any of the antibodies

will tell if the fragments are the same. If the fetus shows isotype other than that of Ig G, it is safe to

2) Cooper, Max et. al. B Lymphocytes In The Immune Response. Elsevier/North-Holland, New

antibodies specific for toxoplasmosis. To answer these questions, a series of experiments have to be

Approximate Word count = 1969
Approximate Pages = 8 (250 words per page double spaced)

Category: Miscellaneous

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