Despite changes in the medical field towards the reduction of infections, the rate of antibiotic resistant infections is on the rise. This paper will look at a couple of different resistant bacteria as well as a new treatment that looks to be hopeful.

To understand the concept of antibiotic resistance, one must first understand how a certain bacteria would be able to fight off an antibiotic. When a person takes an antibiotic the drug kills the weaker or defenseless bacteria, leaving behind the stronger bacteria that are able to resist the the drugs used to kill them normally. These remaining bacteria then begin to multiply a millionfold a day. Antibiotics themselves do not cause the resistance but help to create an ideal situation for it to occur. A patient can develop a drug-resistant infection by either contracting the resistant bacteria from another person to begin with or by having it emerge during antibiotic therapy.

A more in depth description of how resistance occurs is as follows. The resistance results from gene action. Bacteria acquire genes containing resistance in any of three ways. In spontaneous DNA mutation, the bacterial DNA may mutate spontaneously. In a form of

insufficiency secondary to granulomatous disease. He as a result received a kidney transplant. Ten days after the transplant, he developed fever, malaise and right lower quadrant pain at the transplant site. Cultures from the transplanted kidney and from the Jackson-Pratt tube yielded MRSA. Because the patient had a history of severe allergic reaction to vancomycin, Linezolid was initiated at 600mg every 12 hours. After five days the patient had a decrease in symptoms and in drainage from the Jackson-Pratt. Repeat cultures were negative for MRSA, and the patient was converted to oral Zyvox after ten days of intravenous therapy. This patient was still well at his six month follow-up visit. (7)

Linezolid has been shown to be predominately useful in combating gram-positive bacteria. A few examples are S aureus, S epidermisis and S pnemoniae as well as others. There have been a few gram-negative bacteria that Zvyox has been shown effective treating. A fee examples are Pasteurella multocida, Moraxella catarrhalis and

increase central nervous system levels of biogenic amines and increase the risk of acute blood pressure elevation. Based on the findings of this research, the manufactures of Zyvox warn of potential interactions with adrenergic agents, including over-the-counter cold medications that contain pseudoepherine or phenylpropanolamine, and serotonergic agents. To date no other major drug interactions have been identified.(7)

This new class of synthetic antimicrobial agents called oxazolidinones is the proper class for Linelolid. This class works by inhibiting bacterial growth by disrupting protein synthesis at an earlier step than the current protein synthesis inhibitors. When it binds to ribosome, Linezolid actually prevents the formation of certain types of RNA.(7)

Haemophilus influenzae as well as a few others.(7)

ign or symptom that they experience, rather that giving the immune system time to react to the foreign bacteria. Looking toward the future, with education and research more medications than ever could be found for diseases as untouchable as antibiotic resistant microorganisms.

Internet Site: Galewitz, Phil. Battling drug resistance. Http://www.abcnews.go.com/sections/living/Dailynews/antibiodic990325.html

There are also other types of antibiotic resistant bacteria. For example, just four years after mass production of penicillin began, microbes appeared that could resist it. The first known bacteria to become penicillin resistant was Staphylococcus aureus, which is normally harmless. Although, if the bacteria is allowed to overgrow and produce toxins the effects are pneumonia and TSS, or toxic shock syndrome. Approximately twenty years later another resistant bacteria was identified. Streptocococcus pnemonia, or pneumococcus, began to surface

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