The symptoms of ALS include muscle weakness, decrease in muscle coordination and mass, loss of tissue due to a lack of nervous stimulation, possible paralysis, muscle cramps, voice impairment like hoarseness, slow or abnormal speech, difficulty swallowing and breathing, urinary urgency, leg ankle and feet swelling. Additionally, the nerves controlling muscles in

This disease has a gradual onset that progressively worsens until death, which usually occurs within three to five years. There are three types of ALS. In some cases it is known that people inherit ALS, but often there are sporadic or non-inherited cases too. The third kind is Guamanian, because there are so many cases in Guam. Nearly 30,000 people currently have the disease, and 95 percent of them are thought to have the sporadic form. Recently they have identified genetic mutations that appear to cause more than half or these cases. The newly identified mutations involve a protein called EAAT2 where some of the useless introns that are supposed to be cut out of the DNA, are kept, while exons are discarded. This produces defective RNA that leads to a defective EAAT2 protein or no protein at all. EAAT2, normally deactivates and recycles glutamate, a chemical

Some common words found in the essay are:
Gehrig's Disease, ALS Bcl-2, Guam Nearly, Johns Hopkins, Medical Center, Rilutec Pre-clinical, amyotrophic lateral sclerosis, brain spinal, amyotrophic lateral, als bcl-2, nerve cells, gene therapy, cell death, lateral sclerosis,
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