disorder of collagen synthesis associated with broad

spectrum of musculoskeletal problems, most notably bowing

and fractures of the extremities, muscle weakness,

ligamentous laxity, and spinal deformities."

(Binder, 386). Other collagen-containing extraskeletal

tissues, such as the sclerae, the teeth, and the heart

valves are also affected to a variable degree. OI has a

"common feature of bony fragility associated with defective

formation of collagen by osteoblasts and fibroblasts."

(Smith, 1983, 13) This disease, involving defective

development of the connective tissues, is usually the result

of the autosomal dominant gene, but can also be the result

of the autosomal recessive gene. Spontaneous mutations are

common and the clinical presentation of the disease remains

OI is most commonly referred to as "brittle bones",

but other names include: fragilitas ossium, hypolasia of

the mesenchyme, and osteopsathyrosis. Osteogenisis

imperfecta is still not completely understood, and while

there have been advances in diagnosing the disease,

IV are the "less dram- atic outcomes of similar glycine

and after menopause, more fractures occur. The bones are

in 30,000. Type II has a birth incidence of about 1 in

Treatment therefore is predominantly supportive and

since birth or infancy at the National Institutes of Health,

scoliosis, and contractures of the hip flexors were

Group C added coordination activities.

the codon for glycine causes lethal (type II) OI by wrecking

planning should be considered, but not totally based on

fracture rate, as well as hyperpyrexia and constipation

agents has been discussed to decrease bone loss, but no

translucent skin. Discolored (blue-gray or yellow-brown) and

administered during childhood, and is shown to substantially

Some common words found in the essay are:
III IV, Patients OI, Type IV, Conclusion Management, DEFINITION Osteogenisis, Type II, OI Treatment, Foundation OIF, OI Bone, OI Prenatal, osteogenesis imperfecta, iii iv, type ii, et al, types iii iv, types iii, isselbacher 2111, loeb 755, patients oi, osteogenisis imperfecta, symptoms oi, smith et al, al brittle bone, isselbacher 2111 type, brittle bone syndrome,
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