downsyndrom

The chance of getting Down syndrome is approximately one in 700 births, but the risk varies with the age of the mother. The incidence of Down syndrome in children born to 25-year-old mothers is approximately 1 in 1200; the risk increases to approximately 1 in 120 for women older than 40 years. Prenatal tests like amniocentesis and chorionic villus sampling can be used to detect the chromosomal abnormality causing Down syndrome. Maternal blood tests can also suggest the presence of a fetus with Down syndrome when levels of alphafetoprotein are lower than usual, or when levels of unconjugated estriol and human chorionic gonadotrophin are abnormal.

The chromosomal abnormality which generally causes Down syndrome is trisomy-21, or the presence of three 21st chromosomes. As a result, the affected person has 47 chromosomes in all body cells instead of the normal 46. Scientists assume that the reason for the abnormally is the fertilization of an ovum having 24 chromosomes by a sperm with a normal assortment of 23, but they have also found that the sperm can carry the extra

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