that exerts its main effects on the digestive system and the

lungs. This disease is the most common genetic disorder

amongst Caucasians. Cystic fibrosis affects about one in

2,500 people, with one in twenty five being a heterozygote.

With the use of antibiotics, the life span of a person

afflicted with CF can be extended up to thirty years

however, most die before the age of thirteen.1 Since so

many people are affected by this disease, it's no wonder

that CF was the first human genetic disease to be cloned by

geneticists. In this paper, I will be focusing on how the

cystic fibrosis gene was discovered while at the same time,

discussing the protein defect in the CF gene, the

bio-chemical defect associated with CF, and possible

The classical genetic approach to finding the gene that is

responsible for causing a genetic disease has been to first

characterize the bio-chemical defect within the gene, then

to identify the mutated protein in the gene of interest, and

hybridization may have been decreased because of the low

into the cell against its own gradient. This is done in

a significant impact on the Cystic Fibrosis Transmembrane

co-transporter then uses the Na+ gradient to transport Cl-

individuals which are known to travel with genetic

chromosome jumping. To get these probes, DNA from a horse,

cAMP (adenosine 3', 5'-monophosphate) is impaired in cystic

Some common words found in the essay are:
CF RNA, ATP UTP, Defect Studies, Na+ H+-ATPase, Mutations NBF, Fibrosis Gene, Cystic Fibrosis, Caucasians Cystic, Francis Collins, Conclusion Chloride, cystic fibrosis, cf gene, base pairs, cell types, cystic fibrosis gene, membrane spanning, spanning domain, fibrosis gene, blot electrophoresis, membrane spanning domain, epithelial cells, amino acid, northern blot electrophoresis, southern blot electrophoresis, base pair sequence,
Approximate Word count = 2448
Approximate Pages = 10 (250 words per page double spaced)