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Polycystic Ovarian Syndrome

I. A. Polycystic ovarian syndrome (PCOS) was originally described in 1905 by Stein and Leventhal as a syndrome consisting of amenorrhea, hirsutism, and obesity in association with enlarged polycystic ovaries. It is now realized that this relatively common syndrome is an extremely heterogenous clinical syndrome that begins soon after menarche and some authors prefer to refer to it as a syndrome of hyperandrogenic chronic anovulation. In fact, earlier studies of PCOS have focused on ovarian morphological findings and were considered to be important diagnostic criteria. However, it was found that polycystic changes of the ovaries were observed in some normally cycling women. Furthermore, polycystic changes of the ovaries were shown to be associated with other well-defined diseases such as Cushing's syndrome, and an ovarian or adrenal tumor capable of producing androgen.

B. The root of PCOS is an inability to respond properly to insulin, the hormone produced in the pancreas that allows your body's cells to absorb energy from the food you eat. This means your cells don't respond to the normal amount of insulin, so the pancreas pumps out even more. That's what insulin resistance is and it happens when the body turns carbohydrates, bo


S Multiple small ovarian cysts-these may be seen by an ultrasound examination

There are three different ways to make the diagnosis of PCOS:

· Irregular or absent menstrual cycles-PCOS patients may report to a physician for lack of menses or extremely variable menstrual cycles.

· Laboratory testing is important for diagnosis but it is crucial to look at multiple values collectively. A clinician performs blood testing and the results are compared with known normal levels.

Traditional treatments have been difficult, expensive and have limited success when used alone. Infertility treatments include weight loss diets, ovulation medications (clomiphene, follistim, Gonal-F), ovarian drilling surgery and IVF. Other symptoms have been managed by anti-androgen medication (birth control pills, spironolactone, flutamide or finasteride).



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Approximate Word count = 1449
Approximate Pages = 6 (250 words per page double spaced)


  

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