The exact cause of Progeria is unknown, but it is believed due to a single abnormal gene. A gene is the key unit of heredity that is passed from the mother and father to the offspring. Human beings have approximately 80,000 genes. Progeria is thought to be the result of a dominant mutation because the gene in question has one normal copy and one abnormal copy. Because neither parent carries or shows the mutation, each case is believed to represent new mutation that happens at the time of conception.

Research indicates brothers, sisters, and non-identical twins are almost never affected in the same family, the parents are seldom related such as first cousins, and the average difference in ages between father and mother is about six years as compared with the national average of about two years.

Research indicates that the chemical hyaluronic acid may be found in high levels in the urine of Hutchinson-Gilford Progeria Syndrome patients. The same abnormality has been found in Werner Syndrome, which is referred to as the "Progeria of adults." Few other diseases are known in which elevated levels of this chemical are found; suggesting that hyaluronic acid may prove to be a usefu

The majority of doctors and medical geneticists are hardly or not at all familiar with this rare disease. So the treatment of Progeria is limited. Most Progeria patients are put on low-dose aspirin in an attempt to delay the first symptoms of the problematic heart, and sometimes-appropriate drugs can be prescribed to counteract the pain caused by progressive arthritis. But there is no better treatment available, let alone a cure.

The are currently no tests or procedures available to prevent Progeria. There will be no cure or procedure to fix it until scientist are able to fix natures "mistakes" by splicing and correct human genes.

Progeria has a reported incidence of about 1 in 8 million newborns, but the total incidence is estimated to be about 1 in 4 million. It affects both male and female and does not discriminate with race. Since first classified in1886, more than 100 cases have been identified around the world. Children with Progeria have been reported worldwide in places from Algeria to Japan. In Europe, only about ten children are known to have the disease and the number is somewhere between thirty and forty worldwide.

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