Renal Cell Caricnoma

A detailed Summary of Renal Cell Caricnoma

Renal Cell Carcinoma: Genetic Causes

:: How does the Von Hippel-Lindau Syndrome cause Renal Cell Carcinoma?

In the course of researching information about Renal Cell Carcinoma, a cancer of the renal cells located in the kidney, the impact of Von Hippel-Lindau Syndrome and other genetic defects resulting in the formation of Renal Carcinoma was quite interesting. A great risk factor in the diagnosis of Renal Cell Cancer and the initial tumour formation would be the family history of the disease, and/or a family history of the Von Hippel-Lindau Syndrome, both of which are genetic defects that are passed down from generation to generation; analysis of this information would lead to the conclusion that genetic factors play an important role in the formation of the Renal tumours.

Von Hippel-Lindau Syndrome is a genetic birth defect that is passed down through heredity. In a person that suffers from the Syndrome, the Von Hippel-Lindau Tumour Suppressor gene is deformed in certain cells, resulting in cells that turn into tumours more readily then normal cells. If

a tumour does indeed form, the peripheral blood (or blood flowing alongside the tumour) will have a greater chance of picking up the deformed VHL gene. But how does the deformation of the VHL gene result in the formation of the tumour in the first place?

Because Type II is the lethal form of the VHL syndrome, it is further divided down into two additional categories of degree. Because Type II VHL Syndrome results in the formation of tumours, those that do form tumours (especially Renal Cell Carcinoma) are considered to have Type IIB VHL syndrome, and the ones that do not form tumours are considered to have Type IIA VHL Syndrome.

The key to the gene defect is the degree to which the chromosome is deformed. If the deformation is complete and the VHL gene is rendered useless, the patient has a much less, but still greater then one without VHL Syndrome, chance of contracting a VHL-related tumour than one with Type I VHL Syndrome.

It has been discovered recently that the VHL protein that is transcripted from the VHL gene, pVHL or VHL protein, plays an important role in degrading the cancer-causing p

Some common words found in the essay are:
Tumour Suppressor, Type II, Hippel-Lindau Syndrome, Degradation Gene, Cell Carcinoma, Renal Carcinoma, Elongin Cullin-2, VHL Syndrome, Cell Cancer, vhl gene, type ii, vhl syndrome, IIB VHL, renal cell, cell carcinoma, renal cell carcinoma, von hippel-lindau, hippel-lindau syndrome, von hippel-lindau syndrome, hippel-lindau syndrome genetic, ii degradation, renal carcinoma, syndrome genetic, type ii degradation, vhl gene chromosome,

Approximate Word count = 748
Approximate Pages = 3 (250 words per page double spaced)

Category: Science

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