Retinoblastoma
The retinoblastoma families of proteins are key cell cycle regulatory molecules important for the differentiation of various mammalian cell types. The retinoblastoma protein (RB) regulates transcription of a variety of genes either by blocking the activation domain of various activators or by active repression (finding of appropriate promoters). If the RB?s function is lost, it will lead to a variety of cancers and defects in the development of certain cell types. Phosphorylation of RB by cyclin and cyclin-dependent kinases leads to dissociation of RB from E2F (protein receptor), allowing progression into the S-phase. RB has also been proven to have the ability to block cell cycle progression from G1- to the S-phase. (Chan et al, 2001)RB is also a general tumor suppressor, which is associated with a central N (A/B) and C-terminal (pocket domains, which are binding sites for RB) that were defined to have the ability to bind cellular and viral proteins that affect the cell division cycle. Mutations in the pocket domain region are often tumorigenic. These pocket domains are also present in homologues structures of RB that exhibit similar protein binding and functional characteristics pertaining to the cell division cycle. Even
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Some common words found in the essay are:
A/B C-terminal, LBD Ligand-dependent, RB AHR, AHR RB, , S-phase GR, GR AHR, N-terminal A/B, NR GR-, S-phase Chan, et al, al 2001, et al 2001, cell cycle, et al 2000, puga et, puga et al, al 2000, chan et, cycle progression, rb critical, singh et al, singh et, cell division cycle, division cycle,
Approximate Word count = 912
Approximate Pages = 4 (250 words per page double spaced)
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